Gay men in the performing arts: performing sexualities within 'gay-friendly' work contexts

Building on emerging research on ‘gay-friendly’ organisations, this article examines if and how work contexts understood and experienced as ‘gay-friendly’ can be characterised as exhibiting a serious breakdown in heteronormativity. Taking the performing arts as a research setting, one that is often stereotyped as ‘gay-friendly’, and drawing on in-depth interview data with 20 gay male performers in the UK, this article examines how everyday activities and encounters involving drama school educators, casters and peers are informed by heteronormative standards of gay male sexuality. One concern is that heteronormative constructions of gay male sexualities constrain participants’ access to work; suggesting limits to the abilities and roles gay men possess and are able to play. Another concern is that when gay male sexualities become normalised in performing work contexts, they reinforce organisational heteronormativity and the heterosexual/homosexual binary upon which it relies. This study contributes towards theorising ‘gay-friendly’ places of work as heteronormative

Politics and the Bengal Legislative Council 1912-1926

In nineteenth-century Bengal a small section of Hindu society, educated, of high-caste, and with an economy based upon landed rents and professional employment, evolved from its contact with the British a distinctive culture. This gave its members a sense of community and set them apart from the mass of Bengalis. They called themselves bhadralok: 'the respectable people'

Policing and performing gay sexualities : how do gay men neg(oti)ate their sexual identities in the workplace and how does occupational setting frame these processes? : A comparative study into the working lives of gay male police officers and performers

This thesis explores the working realities of gay police officers and performers in relation to ‘gay-friendly’/‘gay-hostile’ worksites and embodied sexual identity, developing an understanding of the meanings gay workers attach to their working lives by mobilising conceptual resources primarily from sociology. Deep seated assumptions pervade current perceptions regarding gay male sexuality and certain occupations. The idea is that there are gay industries like fashion, nursing and the performing arts. In contrast, occupations such as the police and the armed forces are often seen as homophobic, yet a dearth of academic research investigates the lived experiences of gay men located within perceived ‘gay friendly’ or ‘gay hostile’ worksites. Acknowledging this as a missed opportunity for developing empirical insight, I bring to the fore the work realities of some of these overlooked people. Taking the performing arts as an example of a ‘gay-friendly’ occupation, the police as an example of a ‘gay-hostile’ occupation, and drawing on in-depth interview data with 20 gay performers/police officers, I show that the perspectives and experiences of these men allow us to nuance existing research on how LGB employees understand, value and experience ‘gay-friendly’ workplaces, an emerging construct in the organisation studies literature. Focusing on the significance of embodied, sexual identity for the performance of the occupational roles of interest allows this study to consider the relationship between gender and sexuality at work. Literature on the gendered nature of work along with the promising literature on (homo)sexuality in the workplace have proceeded relatively separately, with the exception of the literature on sexualized labour and the commodification of women's (assumed hetero)sexuality in sales-service work (Tyler, 1997). The effect is that the experience and performance of gender and/in/through sexuality at work has been neglected as a topic of empirical investigation. Although sociologists argue that sexuality cannot be understood without reference to gender, and vice versa, few organizational scholars explore the experiences of work with this in mind. This thesis addresses this gap in knowledge. It brings together the perspectives of gay performers and police officers and highlights the prevalence of a „gender imperative‟ throughout the day-to-day lives of these workers. In detailing the workplace experiences of my participants, this thesis also builds on existing studies that tend to focus solely on the general working lives of gay employees. Gay workers face important contextual issues relating to 'passing', 'coming out' and homophobia. Although these are key areas of interest to existing literature, studies so far fail to address these concepts in detail with reference to specific occupational settings. In other words, the research contributes to the area of lesbian, gay and bisexual (LGB) disclosure and management at work. Stigma-based models (Goffman, 1963) are particularly useful here in framing some of the empirical insights of my research

Pin Fracture in Magnetically Controlled Growing Rods: Influence of the Year of Manufacture

Permissions ORIGINAL ARTICLE Pin Fracture in Magnetically Controlled Growing Rods: Influence of the Year of Manufacture Tognini, Martina BEng, MSc*; Hothi, Harry BEng, MSc, PhD†,‡; Dal Gal, Elisabetta MSc*; Henckel, Johann MBBS, MRCS, PhD‡; Shafafy, Masood MBBS, FRCS, FRCS§; Broomfield, Edel MSc∥; Tucker, Stewart MBBS, FRCS, FRCS∥; Skinner, John MBBS, FRCS, FRCS*,‡; Hart, Alister MA, MD, FRCS*,‡ Author Information Journal of Pediatric Orthopaedics ():10.1097/BPO.0000000000002460, June 19, 2023. | DOI: 10.1097/BPO.0000000000002460 OPEN PAP Metrics Abstract Background: Magnetically controlled growing rods (MCGRs) have a known issue with fracture of the internal locking pin resulting in early revisions. The manufacturer reported that rods manufactured before March 26, 2015, had a 5% risk of locking pin fracture. Locking pins made after this date are thicker in diameter and of a tougher alloy; their rate of pin fracture is not known. The aim of this study was to better understand the impact of the design changes on the performance of MCGRs. Methods: This study involves 46 patients with 76 removed MCGRs. Forty-six rods were manufactured before March 26, 2015, and 30 rods after that date. Clinical and implant data were collected for all MCGRs. Retrieval analysis comprised plain radiographs evaluations, force and elongation testing, and disassembly. Results: The 2 patient groups were statistically comparable. We found that 14 of 27 patients implanted with rods manufactured before March 26, 2015 (group I) had a fracture of their locking pins. Three of the 17 patients with rods manufactured after this date (group II) were also found to have a fractured pin. Conclusions: Retrieved rods collected at our center and made after March 26, 2015, had far fewer locking pin fractures than those made before this date; this may be due to the change in pin design

Risk factors associated with poor pain outcomes following primary knee replacement surgery: analysis of data from the Clinical Practice Research Datalink, Hospital Episode Statistics and Patient Reported Outcomes as part of the STAR research programme

OBJECTIVE: Identify risk factors for poor pain outcomes six months after primary knee replacement surgery. METHODS: Observational cohort study on patients receiving primary knee replacement from the UK Clinical Practice Research Datalink, Hospital Episode Statistics and Patient Reported Outcomes. A wide range of variables routinely collected in primary and secondary care were identified as potential predictors of worsening or only minor improvement in pain, based on the Oxford Knee Score pain subscale. Results are presented as relative risk ratios and adjusted risk differences (ARD) by fitting a generalized linear model with a binomial error structure and log link function. RESULTS: Information was available for 4,750 patients from 2009 to 2016, with a mean age of 69, of whom 56.1% were female. 10.4% of patients had poor pain outcomes. The strongest effects were seen for pre-operative factors: mild knee pain symptoms at the time of surgery (ARD 18.2% (95% Confidence Interval 13.6, 22.8), smoking 12.0% (95% CI:7.3, 16.6), living in the most deprived areas 5.6% (95% CI:2.3, 9.0) and obesity class II 6.3% (95% CI:3.0, 9.7). Important risk factors with more moderate effects included a history of previous knee arthroscopy surgery 4.6% (95% CI:2.5, 6.6), and use of opioids 3.4% (95% CI:1.4, 5.3) within three months after surgery. Those patients with worsening pain state change had more complications by 3 months (11.8% among those in a worse pain state vs. 2.7% with the same pain state). CONCLUSIONS: We quantified the relative importance of individual risk factors including mild pre-operative pain, smoking, deprivation, obesity and opioid use in terms of the absolute proportions of patients achieving poor pain outcomes. These findings will support development of interventions to reduce the numbers of patients who have poor pain outcomes

Physical activity during adolescence and the development of cam morphology:A cross-sectional cohort study of 210 individuals

Introduction Cam morphology is a strong risk factor for the development of hip pain and osteoarthritis. It is increasingly thought to develop in association with intense physical activity during youth; however, the aetiology remains uncertain. The study aim was to characterise the effect of physical activity on morphological hip development during adolescence. Methods Cross-sectional study of individuals aged 9-18 years recruited from Southampton Football Club Academy (103 male) with an age-matched control population (52 males and 55 females). Assessments included questionnaires and 3 Tesla MRI of both hips. Alpha angle, epiphyseal extension and epiphyseal tilt were measured on radial images. Results Alpha angle and epiphyseal extension increased most rapidly between ages 12 and 14 years. Soft-tissue hypertrophy at the femoral head-neck junction preceded osseous cam morphology and was first evident at age 10 years. The greatest increase and highest absolute values of alpha angle and epiphyseal extension were colocalised at 1 o'clock. Maximum alpha angles were 6.7 degrees greater in males than females (p=0.005). Compared with individuals who play no regular sport, alpha angles were 4.0 degrees higher in individuals who play sport for a school or club (p=0.041) and 7.7 degrees higher in individuals competing at a national or international level (p=0.035). There was no association with leg dominance. Conclusions Sporting activity during adolescence is strongly associated with the development of cam morphology secondary to epiphyseal hypertrophy and extension with a dose-response relationship. Males participating in competitive sport are at particularly elevated risk of developing cam morphology and secondary hip pathology.</p

Distinct nonequilibrium plasma chemistry of C2 affecting the synthesis of nanodiamond thin films from C2H2 (1%)/H2/Ar-rich plasmas

6 pages, 5 figures, 6 tables.We show that the concentrations of the species C2 (X 1Σg+), C2 (a 3Πu), and C2H exhibit a significant increase when the argon content grows up to 95% in medium pressure (0.75 Torr) radio frequency (rf) (13.56 MHz) produced C2H2 (1%)/H2/Ar plasmas of interest for the synthesis of nanodiamond thin films within plasma enhanced chemical vapor deposition devices. In contrast, the concentrations of CH3 and C2H2 remain practically constant. The latter results have been obtained with an improved quasianalytic space–time-averaged kinetic model that, in addition, has allowed us to identify and quantify the relative importance of the different underlying mechanisms driving the nonequilibrium plasma chemistry of C2. The results presented here are in agreement with recent experimental results from rf CH4/H2/Ar-rich plasmas and suggest that the growth of nanodiamond thin films from hydrocarbon/Ar-rich plasmas is very sensitive to the contribution of C2 and C2H species from the plasma.This work was partially funded by CICYT (Spain) under a Ramón y Cajal project and under Project No. TIC2002- 03235. One of the authors (F.J.G.V.) acknowledges a Ramón y Cajal contract from the Spanish Ministry of Science and Technology (MCYT). One of the authors (J.M.A.) acknowledges partial support from CICYT (Spain) under Project No. MAT 2002-04085-C02-02.Peer reviewe

Mass Spectrometric Analyses of Organophosphate Insecticide Oxon Protein Adducts

OBJECTIVE: Organophosphate (OP) insecticides continue to be used to control insect pests. Acute and chronic exposures to OP insecticides have been documented-to cause adverse health effects, but few OP-adducted proteins have been correlated with these illnesses at the molecular level. Our aim was to review the literature covering the current state of the art in mass spectrometry (MS) used to identify OP protein biomarkers. DATA SOURCES AND EXTRACTION: We identified general and specific research reports related to OP insecticides, OP toxicity, OP structure, and protein MS by searching PubMed and Chemical Abstracts for articles published before December 2008. DATA SYNTHESIS: A number of OP-based insecticides share common structural elements that result in predictable OP-protein adducts. The resultant OP-protein adducts show an increase in molecular mass that can be identified by MS and correlated with the OP agent. Customized OP-containing probes have also been used to tag and identify protein targets that can be identified by MS. CONCLUSIONS: MS is a useful and emerging tool for the identification of proteins that are modified by activated organophosphate insecticides. MS can characterize the structure of the OP adduct and also the specific amino acid residue that forms the key bond with the OP. Each protein that is modified in a unique way by an OP represents a unique molecular biomarker that with further research can lead to new correlations with exposure

Single step syntheses of (1 S)-aryltetrahydroisoquinolines by norcoclaurine synthases

The 1-aryl-tetrahydroisoquinoline (1-aryl-THIQ) moiety is found in many biologically active molecules. Single enantiomer chemical syntheses are challenging and although some biocatalytic routes have been reported, the substrate scope is limited to certain structural motifs. The enzyme norcoclaurine synthase (NCS), involved in plant alkaloid biosynthesis, has been shown to perform stereoselective Pictet–Spengler reactions between dopamine and several carbonyl substrates. Here, benzaldehydes are explored as substrates and found to be accepted by both wild-type and mutant constructs of NCS. In particular, the variant M97V gives a range of (1 S)-aryl-THIQs in high yields (48–99%) and e.e.s (79–95%). A cocrystallised structure of the M97V variant with an active site reaction intermediate analogue is also obtained with the ligand in a pre-cyclisation conformation, consistent with (1 S)-THIQs formation. Selected THIQs are then used with catechol O-methyltransferases with exceptional regioselectivity. This work demonstrates valuable biocatalytic approaches to a range of (1 S)-THIQ

Eukaryotic Y-family polymerases bypass a 3-methyl-2′-deoxyadenosine analog in vitro and methyl methanesulfonate-induced DNA damage in vivo

N3-methyl-adenine (3MeA) is the major cytotoxic lesion formed in DNA by SN2 methylating agents. The lesion presumably blocks progression of cellular replicases because the N3-methyl group hinders interactions between the polymerase and the minor groove of DNA. However, this hypothesis has yet to be rigorously proven, as 3MeA is intrinsically unstable and is converted to an abasic site, which itself is a blocking lesion. To circumvent these problems, we have chemically synthesized a 3-deaza analog of 3MeA (3dMeA) as a stable phosphoramidite and have incorporated the analog into synthetic oligonucleotides that have been used in vitro as templates for DNA replication. As expected, the 3dMeA lesion blocked both human DNA polymerases α and δ. In contrast, human polymerases η, ι and κ, as well as Saccharomyces cerevisiae polη were able to bypass the lesion, albeit with varying efficiencies and accuracy. To confirm the physiological relevance of our findings, we show that in S. cerevisiae lacking Mag1-dependent 3MeA repair, polη (Rad30) contributes to the survival of cells exposed to methyl methanesulfonate (MMS) and in the absence of Mag1, Rad30 and Rev3, human polymerases η, ι and κ are capable of restoring MMS-resistance to the normally MMS-sensitive strain